How frequently can epidural steroid injections be performed? There is no definitive research to dictate the frequency of how often a patient should have epidural steroid injections for low back pain and/or leg pain. In general, it is considered reasonable to perform up to three epidural injections per year. Epidural steroid injection timing varies Typically, epidural steroid injections are done in two-week intervals. However, there is no general consensus in the medical community as to whether or not a series of three injections need always be performed. If one or two injections lessen the patient’s low back pain and/or leg pain, some physicians prefer to save the third epidural steroid injection for any potential recurrences of back pain later in the twelve-month period. By: Rick Staehler, MD November 1999 (updated August 4, 2000)