COX-2 inhibitors — Celebrex On April 7, 2005 the Food and Drug Administration requested that Pfizer suspend sales of Bextra in the United States. As a result, Bextra will no longer be available to patients in the United States. For more information, click to the Bextra homepage. For more information on safe use of COX-2 inhibitors and other NSAIDs, please see Understanding COX-2 inhibitor side effects. COX-2 inhibitors background information Arthritis pain is one of the most prevalent medical problems in the world and afflicts tens of millions of people. For those who suffer from rheumatoid arthritis or osteoarthritis (degenerative arthritis) the pain can be chronic and disabling. Relief from arthritis pain is critical in order improve their functional ability and—importantly—their overall quality of life. Since the synthesis of aspirin in 1897, inhibitors of cyclooxygenase (an enzyme that controls inflammation) have been a major source of relief from arthritis pain. These drugs are now collectively called non-steroidal anti-inflammatory drugs (NSAIDs). They are the world’s most commonly prescribed class of drugs. Non-prescription forms of NSAID's are also very popular (such as ibuprofen). Celebrex - a type of COX-2 inhibitor At the time of this article, the newest generation of NSAIDs is called COX-2 selective inhibitors. A brand name of this type of medication is Celebrex. COX-2 inhibitors such as Celebrex represent a significant advancement in non-steroidal anti-inflammatory treatment for pain because, while they are as efficacious as older NSAIDs, they have far less risk of side effects (such as blood thinning or stomach ulceration). Editorial note: In addition, new potential risks and side effects of COX-2 inhibitors have been studied. For more information, please see Understanding COX-2 inhibitor side effects.

COX-2 inhibitors background information Arthritis pain is one of the most prevalent medical problems in the world and afflicts tens of millions of people. For those who suffer from rheumatoid arthritis or osteoarthritis (degenerative arthritis) the pain can be chronic and disabling. Relief from arthritis pain is critical in order improve their functional ability and—importantly—their overall quality of life. Since the synthesis of aspirin in 1897, inhibitors of cyclooxygenase (an enzyme that controls inflammation) have been a major source of relief from arthritis pain. These drugs are now collectively called non-steroidal anti-inflammatory drugs (NSAIDs). They are the world’s most commonly prescribed class of drugs. Non-prescription forms of NSAID's are also very popular (such as ibuprofen). Celebrex - a type of COX-2 inhibitor At the time of this article, the newest generation of NSAIDs is called COX-2 selective inhibitors. A brand name of this type of medication is Celebrex. COX-2 inhibitors such as Celebrex represent a significant advancement in non-steroidal anti-inflammatory treatment for pain because, while they are as efficacious as older NSAIDs, they have far less risk of side effects (such as blood thinning or stomach ulceration). Editorial note: In addition, new potential risks and side effects of COX-2 inhibitors have been studied. For more information, please see Understanding COX-2 inhibitor side effects.